PREPARE Study Overview
EXTENDED NID 30/40 + SHORT CHARGE TIME < 10 SECS = SHOCK REDUCTION
In Medtronic devices with short and consistent charge times,* strategically programmed detection and therapy parameters can safely reduce shocks in Primary Prevention patients.1,2
Control: EMPIRIC Prospective randomized multicenter trial. Comparison of empiric to physician-tailored programming of ICDs.3
MIRACLE Multicenter InSync Implantable Cardioversion Defibrillation Randomized Clinical Evaluation.4
* Marquis DR/VR and InSync Marquis™ CRT-D devices and forward.
PREPARE PATIENTS WERE LESS LIKELY TO RECEIVE A SHOCK IN THE FIRST YEAR1
Less than 4% of PREPARE patients received an inappropriate shock
Overall safety for PREPARE patients was excellent as measured by arrhythmic syncope and mortality
• Arrhythmic syncope was rare (1.6%)
• All-cause mortality was low (Kaplan-Meier estimated 12-month mortality: 4.9% versus 8.7% for controls)
1 Wilkoff BL, Williamson BD, Stern RS, et al. Strategic programming of detection and therapy parameters in implantable cardioverter-defibrillators reduces shocks in primary prevention patients: Results from the PREPARE (Primary Prevention Parameters Evaluation) Study. J Am Coll Cardiol. August 12, 2008;52(7):541-550.
2 Peterson B, Rogers T. Medtronic, Inc., data on file. August 2008.
3 Wilkoff BL, Ousdigian KT, Sterns LD, Wang ZJ, Wilson RD, Morgan JM, for the EMPIRIC Trial Investigators. A comparison of empiric to physician-tailored programming of implantable cardioverter-defibrillators: results from the prospective randomized multicenter EMPIRIC trial. J Am Coll Cardiol. July 18, 2006;48(2):330-339.
4 Young JB, Abraham WT, Smith AL, et al. Combined cardiac resynchronization and implantable cardioversion defibrillation in advanced chronic heart failure: the MIRACLE ICD trial. J Am Medical Assoc 2003;289:2685-94.
PREPARE Study Design / Results
The objective of the PREPARE Study was to demonstrate that specific strategies for programming of VT/VF detection and therapy parameters in primary prevention ICD and CRT-D patients safely result in significant shock reduction. This file contains information on:
• Study Objective
• Study Design
• Patient / Baseline Characteristics
• Study Endpoints
• Devices and Programming
• Study Results
To download the ppt file - 39 slides - 1.7 MB, click here
Shock Reduction - Clinical Guide
This booklet contains information on:
• PainFREE Rx I and II Studies
• WAVE Study
• EMPIRIC Study
• PREPARE Study
• Programming Considerations to reduce shocks
To download the pdf file - 602 kB - click here